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> Ordovás José M.
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Glucokinase Regulat...
Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome
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Perez-Martinez, Pablo (author)
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Delgado-Lista, Javier (author)
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Garcia-Rios, Antonio (author)
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Mc Monagle, Jolene (author)
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Gulseth, Hanne L. (author)
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Ordovas, Jose M. (author)
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Shaw, Danielle I. (author)
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- Karlström, Brita (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Kiec-Wilk, Beata (author)
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Blaak, Ellen E. (author)
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Helal, Olfa (author)
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Malczewska-Malec, Malgorzata (author)
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Defoort, Catherine (author)
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- Risérus, Ulf (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Saris, Wim H. M. (author)
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Lovegrove, Julie A. (author)
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Drevon, Christian A. (author)
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Roche, Helen M. (author)
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Lopez-Miranda, Jose (author)
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(creator_code:org_t)
- 2011-06-06
- 2011
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 6:6, s. e20555-
- Related links:
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Glucokinase Regulatory Protein (GCKR) plays a central role regulating both hepatic triglyceride and glucose metabolism. Fatty acids are key metabolic regulators, which interact with genetic factors and influence glucose metabolism and other metabolic traits. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been of considerable interest, due to their potential to reduce metabolic syndrome (MetS) risk. Objective: To examine whether genetic variability at the GCKR gene locus was associated with the degree of insulin resistance, plasma concentrations of C-reactive protein (CRP) and n-3 PUFA in MetS subjects. Design: Homeostasis model assessment of insulin resistance (HOMA-IR), HOMA-B, plasma concentrations of C-peptide, CRP, fatty acid composition and the GCKR rs1260326-P446L polymorphism, were determined in a cross-sectional analysis of 379 subjects with MetS participating in the LIPGENE dietary cohort. Results: Among subjects with n-3 PUFA levels below the population median, carriers of the common C/C genotype had higher plasma concentrations of fasting insulin (P = 0.019), C-peptide (P = 0.004), HOMA-IR (P = 0.008) and CRP (P = 0.032) as compared with subjects carrying the minor T-allele (Leu446). In contrast, homozygous C/C carriers with n-3 PUFA levels above the median showed lower plasma concentrations of fasting insulin, peptide C, HOMA-IR and CRP, as compared with individuals with the T-allele. Conclusions: We have demonstrated a significant interaction between the GCKR rs1260326-P446L polymorphism and plasma n-3 PUFA levels modulating insulin resistance and inflammatory markers in MetS subjects. Further studies are needed to confirm this gene-diet interaction in the general population and whether targeted dietary recommendations can prevent MetS in genetically susceptible individuals.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Perez-Martinez, ...
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Delgado-Lista, J ...
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Garcia-Rios, Ant ...
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Mc Monagle, Jole ...
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Gulseth, Hanne L ...
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Ordovas, Jose M.
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show more...
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Shaw, Danielle I ...
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Karlström, Brita
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Kiec-Wilk, Beata
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Blaak, Ellen E.
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Helal, Olfa
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Malczewska-Malec ...
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Defoort, Catheri ...
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Risérus, Ulf
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Saris, Wim H. M.
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Lovegrove, Julie ...
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Drevon, Christia ...
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Roche, Helen M.
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Lopez-Miranda, J ...
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show less...
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PLOS ONE
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Uppsala University